Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product competes with ATP.

Target IC₅₀: 1.2 µM for human recombinant Csk

Primary Targethuman recombinant Csk

General description

A potent, selective, reversible, and ATP-competitive inhibitor of Src family tyrosine kinases (IC₅₀ = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR tyrosine kinase even at concentrations as high as 50 µM.

A substituted triazoloquinoline-1-thione compound that acts as a potent, ATP-competitive, reversible and selective inhibitor of Src family tyrosine kinases (IC₅₀ = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR even at concentrations as high as 50 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kilimnik, A., et al. 2003. Cell. Mol. Biol. Lett.8, 588.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)